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Article
June 1920

THE EFFECT OF ACUTE YELLOW ATROPHY ON METABOLISM AND ON THE COMPOSITION OF THE LIVER

Author Affiliations

NEW YORK

From the Hospital of The Rockefeller Institute for Medical Research.

Arch Intern Med (Chic). 1920;25(6):693-704. doi:10.1001/archinte.1920.00090350120009
Abstract

In the present paper we report chemical analyses of the blood and urine made in a case of acute yellow atrophy for three days before death, together with analysis of the liver removed at necropsy three hours after death. The study was directed especially toward the nitrogen metabolism and the acid-base balance of the patient. Besides other determinations, including those of urea, quantitative estimations of the amino-acid nitrogen in the urine, blood and liver were performed for the first time in such a case, so far as we can ascertain.

The results are of interest in two connections: (1) the pathologic metabolism of acute yellow atrophy, and (2) the rôle of the liver in the normal handling of nitrogenous products. The condition is one in which the liver as a functioning organ suffers almost complete, if not complete, destruction, without similar apparent injury to other organs; and the failure in

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