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Article
July 1920

A STUDY OF RENAL FUNCTION AND THE ASSOCIATED DISTURBANCE IN THE ACID-BASE EQUILIBRIUM OF THE BLOOD IN CERTAIN EXPERIMENTAL AND NATURALLY ACQUIRED NEPHROPATHIES

Author Affiliations

CHAPEL HILL, N. C.

From the Laboratory of Pharmacology of the University of North Carolina.

Arch Intern Med (Chic). 1920;26(1):1-37. doi:10.1001/archinte.1920.00100010004001
Abstract

During the past fourteen years, the work in this laboratory has been confined largely to a study of different types of acute experimental nephropathy and of certain naturally acquired chronic nephropathies. Four hundred and forty-nine animals have been employed in the various series of experiments. In a large number of these animals some form of renal functional test was used. In 132 animals a functional study of the kidney was the primary object of the investigation. In this latter group of animals a variety of functional tests were made use of. With this large amount of experimental data available, a study has been undertaken of the function of the kidney in different types of nephropathic processes and of the association of changes in the acid-base equilibrium of the blood with variations in the functional and pathological response on the part of the kidney.

In the earlier series of experiments1 which

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