The results of a comparative study of the clinical and laboratory data for determining thyroid deficiency are reported herewith. There is very little difficulty in recognizing the average well-developed case of myxedema or cretinism, but our observations show that cases of mild thyroid deficiency are probably more numerous than has previously been supposed; also that some will remain unrecognized unless special methods are used in diagnosis and control of treatment.
A series of cases of thyroid disease were selected for study. Certain of these cases had been previously diagnosed definitely hypothyroid. Other patients had long been seeking relief from indefinite ill-health previously undiagnosed, which no form of treatment seemed to alleviate. With the exception of one patient, (Case 1940), a child, 2 years old and too young for special methods of examination, the group could definitely be diagnosed by aid of combined laboratory and clinical methods as thyroid deficiency cases.
JANNEY NW, HENDERSON HE. CONCERNING THE DIAGNOSIS AND TREATMENT OF HYPOTHYROIDISM. Arch Intern Med (Chic). 1920;26(3):297-318. doi:10.1001/archinte.1920.00100030041005