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The basis of the findings recorded here are the observations made in thirteen cases in which the Goetsch epinephrin test was applied. These cases were suggestive of thyroid disease, diagnosed as such by Drs. Baetjer and Miller. The work was carried on simultaneously with that of Cowie, and the results obtained were similar, except that Cowie's work was not done in cases diagnosed as hyperthyroidism and, therefore, did not show such a lymphocyte increase.
One of the early blood changes in toxic goiter is an increase in the ratio of lymphocytes and polymorphonuclear leukocytes and also an actual rise in the percentage of lymphocytes.
It has been shown by other observers that epinephrin administered subcutaneously will increase the leukocyte count and the erythrocyte count. In this experiment, however, the erythrocyte increase was not dwelt on. The main object was to show the change which takes place in the differential leukocyte
TROTT RM. THE BLOOD PICTURE BEFORE AND AFTER GOETSCH EPINEPHRIN TEST. Arch Intern Med (Chic). 1920;26(3):352-356. doi:10.1001/archinte.1920.00100030096009