Since the first presentation of the colloidal gold reaction by Lange1 in 1912, both its technic and significance have been discussed at great length in the current medical literature, particularly in Germany and this country, until it has now an undisputed place in the routine examination of spinal fluids as a definite aid to the diagnosis of many affections of the central nervous system.
A perusal of the voluminous literature on this subject discloses a noticeable absence of attention given to the effect of antisyphilitic treatment on this very important reaction. Our information on this subject comes largely from chance comments interspersed at various points in general discussions of the colloidal gold reaction by different authors. And, after compiling these various bits of information, one is impressed by the great variance of opinion expressed and the lack of proof or detailed discussion advanced as a basis for such opinions. In
WARWICK M. THE EFFECT OF ANTISYPHILITIC TREATMENT ON THE COLLOIDAL GOLD REACTION. Arch Intern Med (Chic). 1921;27(2):238-254. doi:10.1001/archinte.1921.00100080101007