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Article
February 1921

THE SIGNIFICANCE OF THE EMBOLIC GLOMERULAR LESIONS OF SUBACUTE STREPTOCOCCUS ENDOCARDITIS

Arch Intern Med (Chic). 1921;27(2):262-264. doi:10.1001/archinte.1921.00100080118009
Abstract

In a previous paper1 based on a study of the kidneys of twenty-three cases of subacute bacterial endocarditis due to the Streptococcus anhemolyticus (Streptococcus viridans), it was found that in twenty-three of the cases a distinctive pathologic lesion existed in the glomeruli. This pathologic picture had previously been described by Loehlein2 in two cases of the disease. As a result of our more extensive study, we were inclined to believe that the lesion was specific for this disease.3

We were also able to demonstrate at that time that the lesions, as had been suspected by Loehlein, are due to small bacterial emboli which destroy one or more loops at some part of a glomerulus. Eventually, complete organization of this damaged segment takes place by invasion of fibroblasts from the periphery of Bowman's capsule.

The salient features of the lesion which serve to differentiate it from other types of glomerular disease

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