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March 1921

ADMINISTRATION OF A PITUITARY EXTRACT AND HISTAMIN IN A CASE OF DIABETES INSIPIDUS

Author Affiliations

IOWA CITY

From the Chemical Research Laboratory of the Department of Theory and Practice of Medicine and Clinical Medicine, in cooperation with the Department of Home Economics and the Graduate College, the State University of Iowa.

Arch Intern Med (Chic). 1921;27(3):351-360. doi:10.1001/archinte.1921.00100090088006
Abstract

We have recently had the opportunity to study experimentally a rather severe case of diabetes insipidus. Our observations include the effect of lumbar puncture, the administration of pituitary extract hypodermically and by mouth, the effect of histamin injection, the nitrogenous metabolism before and as affected by pituitary extract, the blood constituents and the carbohydrate tolerance.

REPORT OF CASE  J. S., male, white, aged 24 years, single, a painter and mechanic, and an overseas man, was referred to the State University of Iowa Hospital, April 25, by Dr. F. H. Lamb of Davenport, Iowa, for chronic syphilis and polyuria.

Family History.  —The family history was unimportant; the patient stated, however, that one brother is a great water drinker.

Present Illness.  —The patient complained of loss of appetite, pain in the back and lower abdomen, occasional dimness of vision, dizziness, coldness and chills, polydipsia and polyuria, general weakness, and some loss in

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