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Article
October 1921

THE CHEMISTRY AND CLINICAL SIGNIFICANCE OF UROBILIN

Author Affiliations

NEW YORK

From the Medical Clinic, Presbyterian Hospital, Columbia University.

Arch Intern Med (Chic). 1921;28(4):475-483. doi:10.1001/archinte.1921.00100160110008
Abstract

Renewed interest in the physiology and clinical significance of urobilin has been aroused by the work of Wilbur and Addis1 in this country, and by that of H. Fischer2 and collaborators abroad. Clinical reports by Schneider,4 Howard and Hansmann,5 McCrudden,6 Robertson,7 Giffin, Stanford and Szlapka,8 have served further to illustrate the practical value of urobilin determinations, in the bile, urine and feces.

In the present article, I wish briefly to review the present status of the urobilin question, and to tabulate the results of about 100 determinations on the urine and stool.

If we could determine accurately the daily excretion of bilirubin, it might aid in gaining an insight into this particular function of the liver and also afford a clue as to the extent of blood destruction, for at present it is generally believed that bilirubin is directly derived from hematin. Unless the patient or experimental animal has a

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