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Article
November 1921

STUDIES ON ERYTHROCYTES, WITH SPECIAL REFERENCE TO RETICULUM, POLYCHROMATOPHILIA AND MITOCHONDRIA

Author Affiliations

BOSTON

From the laboratory of the Department of Medicine of the Harvard Medical School.

Arch Intern Med (Chic). 1921;28(5):511-549. doi:10.1001/archinte.1921.00100170012002
Abstract

INTRODUCTION  It has been suggested (Shipley,1 Sappington2) that the study of the mitochondria in the erythrocytes in the circulating blood would be of value clinically in estimating the state of activity of the bone marrow.The term mitochondria was introduced by Benda3 in 1899 to designate certain threadlike granules which he had noted in his studies on spermatogenesis. Many authors had previously described similar protoplasmic granules under various terms. The protoplasmic fila of Flemming4 included some poorly fixed mitochondria, and a large percentage of the bioblasts of Altmann5 were mitochondria. Cowdry6 has carefully reviewed a very extensive literature on the subject and critically examined the descriptions of protoplasmic granules as given by a great many investigators under a very varied terminology. He finds that granules having definite characteristics and hence capable of being separated from other cytoplasmic constituents have been observed and described in the protoplasm of almost every type

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