REPORT OF CASE
—A male, aged 44 years, entered the medical clinic in May, 1920, with symptoms and signs of a midbrain lesion, possibly due to a tuberculoma. He was almost completely aphasic and no history of his family antecedents or his previous medical condition could be elicited.
—The first two routine examinations of the urine revealed a slight reduction with Fehling's solution but no other abnormality was then noted. A day or two later, we were struck with the appearance of a specimen of urine because of its peculiar mahogany brown color. We were told that it belonged to our patient with the midbrain lesion and that it reduced Fehling's solution, which first appeared brownish black and later gave a reddish copper sediment. We naturally immediately suspected alkapton as the cause for the change. Our suspicions were further confirmed when it was found that the color of
GIBSON RB, HOWARD CP. A CASE OF ALKAPTONURIA WITH A STUDY OF ITS METABOLISM. Arch Intern Med (Chic). 1921;28(5):632-637. doi:10.1001/archinte.1921.00100170133008