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December 1921


Author Affiliations


From the Laboratory of Surgical Research, Harvard Medical School, and Surgical Clinic, Peter Bent Brigham Hospital.

Arch Intern Med (Chic). 1921;28(6):773-803. doi:10.1001/archinte.1921.00100180091006

INTRODUCTION AND HISTORY  It has been known for a long time that tumors and other pathologic lesions in the region of the sella turcica are attended by far-reaching pathologic alterations in other parts of the body. For some time also it was a matter of dispute among clinicians as to whether the symptoms were due essentially to lesion of the pituitary gland or of the immediately adjacent base of the brain (Erdheim1). Recently this controversy has arisen anew in the contradictory articles of Leschke2 and Marañón.3In 1907 Paulesco4 opened the way to a solution of the question by developing a method of operative approach to the region of the sella. By this method, perfected by Cushing and developed by him and his associates, operative procedures on the pituitary gland became relatively easy.Cushing5 was the first to note, after experimental lesions of the pituitary in dogs, the development of

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