[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.62.139. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 1922

THE SEAT OF THE EMETIC ACTION OF THE DIGITALIS BODIES

Author Affiliations

NEW YORK CITY

From the Laboratory of Pharmacology of Cornell University Medical College.

Arch Intern Med (Chic). 1922;29(5):690-704. doi:10.1001/archinte.1922.00110050140009
Abstract

Emetics are divided commonly into two classes: (a) Those which irritate certain nerve endings in the gastric mucous membrane; (b) those which stimulate the vomiting center in the medulla directly.

Hatcher and Eggleston1 showed that emesis follows the intravenous injection of any one of the several digitalis bodies in dogs, even after the removal of the gastro-intestinal tract, and while they considered it possible that vomiting is due to a reflex arising in some peripheral structure, such as the esophagus, they came to the conclusion that all the evidence available points to the vomiting center as the seat of the emetic action of all of the digitalis bodies.

The fact that these bodies differ so widely in their chemical composition directed our attention to the coincidence that every member of the group shows a greater or less parallelism between its cardiac and emetic activities, though the several members of the

First Page Preview View Large
First page PDF preview
First page PDF preview
×