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July 1922

THE ELIMINATION OF ARSENIC IN THE URINE OF SYPHILITIC PATIENTS AFTER INTRAVENOUS INJECTION OF ARSPHENAMIN

Author Affiliations

PHILADELPHIA

From the Dermatological Research Institute, Philadelphia. (Investigations aided by funds accruing from the preparation of arsphenamin.)

Arch Intern Med (Chic). 1922;30(1):85-93. doi:10.1001/archinte.1922.00110070088006
Abstract

Although the literature on arsphenamin has become extremely voluminous, yet there are relatively few reports of work done on the important subject of arsenic elimination after intravenous injection of this drug in which the arsenic determinations have been made by modern, accurate methods. Moreover, the older literature from 1910 to 1913 deals mostly with the intramuscular and subcutaneous methods of administration which are no longer in vogue today. For this reason, it has been deemed advisable to reinvestigate this subject on a series of carefully controlled patients with the use of more recent and acceptable methods.

REVIEW OF THE LITERATURE  The literature up to 1913 has been thoroughly reviewed by Ullman.1 We have gone over this literature and after thorough analysis, have decided to omit from this discussion the work of those authors2 who used inadequate methods for the destruction of the organic matter of the urine or tissues or

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