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September 1922

EXPERIMENTAL REPRODUCTION OF THE SPECIFIC HISTOPATHOLOGY OF INFLUENZA

Author Affiliations

NEW YORK

From the Pathological Department of the Mount Sinai Hospital.

Arch Intern Med (Chic). 1922;30(3):307-320. doi:10.1001/archinte.1922.00110090040003
Abstract

It was realized rather early in the recent pandemic of influenza that by the time patients died secondary infections with various pyogenic organisms had usually taken place, which more or less completely obliterated evidences of the original disease. From numerous bacteriologic studies, it was evident that the bacteria recovered from the lungs after death had secondarily invaded the damaged organs from the upper respiratory tract. Traditional belief made many observers reluctant to assign a similar rôle to the B. influenzae of Pfeiffer, But even this organism was finally relegated to a secondary rôle by work such as that of MacCallum,1 which demonstrated that although it might be present in a large percentage of the lungs of persons dying of the disease in one part of the country, the bacillus of Pfeiffer was correspondingly rare in the lungs in other parts of the country where, at the time, it happened to

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