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September 1922


Author Affiliations


From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital.

Arch Intern Med (Chic). 1922;30(3):397-406. doi:10.1001/archinte.1922.00110090130010

In a preliminary paper1 on this subject the results of some observations on the glucose mobilization rate in hyperthyroidism were reported. In this paper the results will be exhibited in greater detail. Ten normal controls and ten well marked cases of exophthalmic goiter have been studied under identical conditions. All the cases of hyperthyroidism were of the same type, i. e., exophthalmic goiter, with all the clinical manifestations of a well marked thyrotoxicosis.

The object of the experiments was to obtain some insight into the mechanism of so-called decreased carbohydrate tolerance in cases of hyperthyroidism. Through studies of the change in the blood sugar, the respiratory quotient and the total metabolism, before and after glucose ingestion, we derived our data for computing the carbohydrate utilization.

The procedure need not be gone over again in detail as it was clearly outlined in the preliminary paper. A Tissot spirometer, equipped with a

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