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Acidosis is now generally known to be present in various diseases, such as diabetes, nephritis, uremia, and when violent diarrhea and vomiting occur clinically, there is also a rapid decrease in the body fluids. In most cases of cholera, the victim falls into a state of temporary inanition, and in consequence of the action of the toxin on the kidneys, so-called cholera nephritis very often develops. The decrease of blood alkali and the accumulation of acid in the body, make the existence of acidosis a certainty.
Sellards noted the remarkable tolerance of the urine to alkali, while Rogers observed a notable decrease of alkali in the blood.
During the cholera epidemic of last year, 529 cases were treated in the Dairen Isolation Hospital. Owing to a lack of apparatus Van Slyke's method for the determination of acidosis could not be employed. Traube's quinin method was resorted to instead, and the
TSURUMI M, TOYODA T. CHOLERA ACIDOSIS AND ITS THERAPY. Arch Intern Med (Chic). 1922;30(6):797–800. doi:10.1001/archinte.1922.00110120116006