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Article
January 1923

AN EXPERIMENTAL AND CLINICAL STUDY OF QUINIDIN SUPHATE: II. CLINICAL

Author Affiliations

CLEVELAND

From the Medical Clinic of Lakeside Hospital and Western Reserve University.

Arch Intern Med (Chic). 1923;31(1):36-55. doi:10.1001/archinte.1923.00110130039004
Abstract

In the short time that quinidin has been under intensive investigation, a considerable number of facts regarding its action and uses have become generally apparent. It is well recognized that quinidin therapy is not applicable outside the field of disordered cardiac mechanism, and is furthermore limited to two general classes of disorder within that field: (1) The paroxysmal tachycardias, including premature contractions occurring singly or in groups; (2) disorders due to circus movement within the auricle, comprising, (a) auricular flutter; (b) auricular fibrillation.

Clinical experience with arrhythmias of the first class is still extremely meager. Hamburger1 mentions a case of auricular paroxysmal tachycardia, but reserves discussion until more extended observations shall have been made. Boden2 states that quinidin was tried with favorable results in twenty-two cases showing premature beats, mostly ventricular in origin; and that in six cases of atrioventricular or ventricular paroxysmal tachycardia cessation of paroxysms was secured four

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