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September 1923


Author Affiliations


From the University Division of the Minneapolis General Hospital and the Graduate School of the University of Minnesota.

Arch Intern Med (Chic). 1923;32(3):343-352. doi:10.1001/archinte.1923.00110210032004

The literature dealing with the alimentary glucose tolerance test1 has been recently reviewed by Macleod,2 Folin and Berglund,3 John,4 MacLean and de Wesselow.5 In addition to its use as a diagnostic aid in diabetes, according to Sherrill,6 John4 and others, it has assumed importance in a wide variety of diseases.7 Janney and Isaacson8 have improved on the technic as first applied. By doing both blood and urine sugar analyses, the factor of renal permeability has been overcome so that it is rather a reading of glycemia than of glycosuria. In addition, the amount of glucose to be given varies with the weight of the person.

Intestinal absorption, as a variable factor, has long been recognized. Janney and Isaacson8 discuss this at length and point to the work of Janney9 and of Fisher and Wishart10 to prove that it is unimportant. Their proof is not convincing. They state that 66 per

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