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November 1923

EXPERIMENTAL INFECTIOUS STREPTOCOCCUS ENDOCARDITIS AND ITS ARSENICAL THERAPY (SODIUM CACODYLATE)

Author Affiliations

The John Jay Borland Fellow in Medicine CHICAGO

Arch Intern Med (Chic). 1923;32(5):727-745. doi:10.1001/archinte.1923.00110230083008
Abstract
  • Definition

  • Etiology

  • Experimental Observations by Others

  • Mortality Reports

  • Specific Therapy

  • Animal Experimentation

    • Production of Endocarditis

      1. Methods

      2. Results

    • Arsenical Therapy

      1. Methods

      2. Results

  • Discussion

  • Conclusions

DEFINITION  Names have been introduced at various times descriptive of the pathologic changes occurring in heart valves following bacterial infections. Such names as simple acute endocarditis, benign, infectious, bacterial, chronic, malignant, septic and ulcerative endocarditis and more recently endocarditis lenta and subacute bacterial endocarditis have been suggested by clinicians. Litten,1 in 1900, classified infections of the heart valves into acute, malignant and chronic, by the first two meaning infections causing in patients severe septic symptoms and death in a short time, by the last one mentioned those less severe and of much longer duration. Litten's classification prompted a lively discussion regarding septic or malignant endocarditis referred to by the early writers. Simons2 prefers the term "bacterial endocarditis," a designation more accurate than "malignant," "septic" or "ulcerative." Libman3

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