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Article
November 1923

OBSERVATIONS ON THE EFFECTS OF INSULIN IN THE TREATMENT OF DIABETES MELLITUS

Author Affiliations

MONTREAL, CANADA

From the Department of Metabolism of the Montreal General Hospital.

Arch Intern Med (Chic). 1923;32(5):796-810. doi:10.1001/archinte.1923.00110230152014
Abstract

My object is to present the data obtained in a number of cases of diabetes mellitus following the administration of insulin. (These observations were made possible through the generosity of the diabetic committee of the University of Toronto who supplied this hospital with approximately 400 units of the extract weekly.) The first experience we had was with a patient with severe diabetes, and it was soon found that the weekly supply of insulin would be sufficient to treat intensively only about one case a week. For this reason the greater part of the insulin was applied to the study of various problems concerning the diabetic patient, and in only emergency cases was there any serious attempt made at treatment. A number of patients with severe diabetes previously discharged were, therefore, readmitted for observation. I record the following observations:

  1. Effect of insulin on a case of incipient diabetic coma with

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