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Article
December 1923

RENAL INJURY PRODUCED IN RABBITS BY DIETS CONTAINING MEAT

Author Affiliations

ANN ARBOR, MICH.

From the Department of Internal Medicine, University of Michigan Medical School.

Arch Intern Med (Chic). 1923;32(6):850-869. doi:10.1001/archinte.1923.00110240043003
Abstract

In a recent communication1 we described the atherosclerosis which is produced in rabbits that are fed diets rich in meat proteins. The kidneys of the same rabbits presented abnormalities which form the subject of this paper.

The composition of the diets and the selection and care of the animals was described in the previous paper in the following words:

The animals were fed diets containing two different concentrations of protein. Lean beef muscle mechanically freed of fat and then dried and powdered2 was the chief source of protein. Ordinary white bread flour mixed in equal parts with bran, supplied carbohydrate and roughage. The first diet was made by stirring together 1,000 gm. of the powdered beef; 2,000 gm. of the flour, bran mixtures; 20 gm. sodium chlorid; 50 gm. baking powder and enough water to produce a stiff dough. The latter was then spread thickly in oiled pans and baked

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