During the winter of 1922-1923, at St. Luke's Hospital, New York City, we had the opportunity to study the effect of insulin in thirty cases of diabetes, most of them severe. We report in detail thirteen in which the patients have been under long continued treatment.
Our work confirms the reports of the value of insulin in the treatment of diabetes in the publications of Drs. Banting, Best and McCleod, and others of the Toronto group. Our method in general has depended on whether there has been a dangerous amount of acidosis present or not. In cases of coma or severe acidosis insulin was given immediately, and the ordinary methods of treatment, such as forced fluids by mouth or rectum with bicarbonate of soda in addition, were employed. When only a moderate amount or no acidosis was present the patients were, in the earlier cases of our series, rendered sugar
FRISSELL LF, HAJEK J. INSULIN IN THE SEVERER FORMS OF DIABETESWITH REPORT OF CASES. Arch Intern Med (Chic). 1924;33(2):230–250. doi:10.1001/archinte.1924.00110260076007