A study of the combined action of two drugs is of both theoretical and practical interest. From the practical standpoint, the result of such a study may shed light on the value of either drug in the abnormal states encountered in disease; with more certainty, it may give information regarding the efficacy of one drug as a physiologic antidote for the other. The comparative frequency of morphin poisoning, the frequent subcutaneous administration of the poison and the fact that considerable time may elapse before the patient comes under treatment, all combine to render it desirable that we possess a satisfactory physiologic antidote against morphin. For this purpose, several drugs have been proposed; of these, caffein alone seems to have met with almost universal approbabation. The present investigation was undertaken to ascertain whether this favorable view could be supported by experimental evidence.
EXPERIMENTS WITH MORPHIN AND CAFFEIN PERFORMED ON CATS
HASKELL CC, RUCKER JE, SNYDER WS. THE VALUE OF CAFFEIN AS AN ANTIDOTE FOR MORPHIN. Arch Intern Med (Chic). 1924;33(3):314-320. doi:10.1001/archinte.1924.00110270035004