Syphilis of the aortic orifice is now recognized as the most common cause of aortic insufficiency in adults. The disease is so frequently associated with syphilis of the aorta itself that, from a pathologic standpoint, one is not justified in considering the two conditions separately. Indeed, whether the aortic leaflets are ever primarily and exclusively attacked by syphilis, true syphilitic endocarditis, is still an open question. This, as well as several other interesting problems presented by the disease can best be studied by correlating clinical and pathologic observations on a large series of patients. Although the group of cases here discussed is not large, certain facts were observed which may serve as a basis for further study of what may be called syphilitic cardio-aortic disease.
This paper is based on the clinical and pathologic studies of twentyfive patients, who with but two exceptions, were under my observation at Cleveland City
SCOTT RW. SYPHILITIC AORTIC INSUFFICIENCY. Arch Intern Med (Chic). 1924;34(5):645-657. doi:10.1001/archinte.1924.00120050062003