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Article
December 1924

THE RELATION OF THE SUPRARENALS TO CHOLESTEROL METABOLISM

Author Affiliations

CLEVELAND; NEW HAVEN, CONN.

From the Section of Surgery, Yale University School of Medicine.

Arch Intern Med (Chic). 1924;34(6):841-866. doi:10.1001/archinte.1924.00120060108007
Abstract

It has been shown by histologic and chemical studies that the cortex of the suprarenal is particularly rich in lipoids, especially cholesterol and its esters. It has also been demonstrated that these cortical cells hypertrophy during the hypercholesterinemia of pregnancy1 and that pregnant animals survive fatal extirpation of the suprarenals much longer than nonpregnant animals.2 In addition to this, several workers have noted in the experimental hypercholesterinemia due to high cholesterol feeding, and also in the pathologic and physiologic hypercholesterinemias, that there has been a constant increase in the lipoid content of the cortex of the suprarenals. Wacker and Hueck3 have demonstrated that animals that had been fed cholesterol preoperatively definitely lived longer after bilateral suprarenalectomy. These observations, together with the work of Chauffard and his school in France, and the German workers (Aschoff, Rothschild, Landau and McNee) strongly suggest that some definite relationship exists between the suprarenal glands and

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