Cholecystitis is frequently associated with a certain degree of pancreatitis. Of 1,290 cases of diseases of the gallbladder and bile duct reported by Judd,1 347 or 26.8 per cent. had associated pancreatitis. In his cases, the clinical history did not, as a rule, suggest pancreatitis. The condition was determined at the time of operation by enlargement, hardening or edema of the pancreas. Deaver believes that cholecystitis causes a pancreatic lymphangitis, which condition precedes interstitial pancreatitis. Pancreatitis is sufficiently far advanced in over one fourth of the cases of gallbladder disease operated on to cause a macroscopic change in the organ. Another interesting illustration of the intimate relationship between gallbladder and pancreatic disease is the not infrequent occurrence of glycosuria in long standing cholecystitis.
In routine examination of the fasting duodenal juice for pancreatic enzymes, we frequently encountered an absence of, or a decrease in, the amount of one or more
PIERSOL GM, BOCKUS HL. PANCREATIC ENZYMES IN CHOLECYSTITIS. Arch Intern Med (Chic). 1925;35(2):204-213. doi:10.1001/archinte.1925.00120080056005