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April 1925


Arch Intern Med (Chic). 1925;35(4):423-432. doi:10.1001/archinte.1925.00120100021002

In any report of experimental work on chronic peptic ulcer, the method of arriving at a diagnosis of ulcer is important. I chose twenty-nine patients who presented: (a) carefully elicited clinical histories of attacks of regularly recurring epigastric distress with definite relation to meal taking; (b) relief from pain by eating, by emptying the stomach and by alkalis (all of these repeatedly demonstrated during a ten or fourteen day period of hospital observation while on a diagnostic "testout"),1 and (c) complete relief from pain while on ulcer treatment. This lasted for four weeks in the hospital and continued for months at home. (The follow-up on these patients extends over from one to two years in the Sippy routine.)

The above named conditions (a, b and c) were all characteristically present in the twenty-nine patients. In addition, (d) a number had gastric peristaltic waves and other evidence of chronic obstruction at

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