In the preceding paper, it has been shown that an alkaline tide can be demonstrated in most cases in which hydrochloric acid is secreted by the stomach, but is not present in cases of achlorhydria or in subjects who secrete very little acid. The present paper is a brief report of a few experiments made to determine how much acid the stomach must secrete to cause the changes in the urine.
In the experiments reported in the preceding article, gastric analyses and alkaline tide determinations were not made simultaneously. There are obvious objections to comparing directly results so obtained. In some cases, the gastric curves found on the same subject resemble each other closely;1 in others, this is not true.2 In some instances, variations in the acidity in different parts of the stomach3 may account for the findings, for the tube may rest in different parts of the organ, but
HUBBARD RS, ALLEN EG. SIMULTANEOUS DETERMINATIONS OF GASTRIC ACIDITY AND THE ALKALINE TIDE IN URINE. Arch Intern Med (Chic). 1925;35(5):586-593. doi:10.1001/archinte.1925.00120110052007