The purpose of this paper is to present the results of a clinical and laboratory study of sensation arising from stimulation of the duodenum. The chief of these sensations is nausea. Since nausea is a sensation, its presence must be identified with some objective or motor phenomenon before it can be studied by animal experimentation. Up to the present, no adequate studies dealing with the mechanism of nausea have been noted in the literature. I therefore believe that the present experiments open up a field for investigation, and hope that the data presented may stimulate further work on this important subject.
The present study was made on a series of sixty ambulatory patients, the majority of whom complained of gastro-intestinal disturbances. In the number were many women, and prominent among their complaints were symptoms suggestive of circulatory instability. The Rehfuss tube was used for duodenal drainage. The stomach was
KEETON RW. NAUSEA AND RELATED SENSATIONS ELICITED BY DUODENAL STIMULATION. Arch Intern Med (Chic). 1925;35(6):687-697. doi:10.1001/archinte.1925.00120120018002