Typhoid fever is perhaps one of the best studied diseases as regards pathogenesis, the clinical course and the anatomic changes that it causes. Thanks to the bacteriologic and biologic methods of investigation, however, we have found that it can take ever so many clinical forms and that it may simulate many morbid conditions. We also must state that it is necessary to make a strict distinction between typhus abdominalis proper and other infections caused by the bacillus of Eberth.
Typhoid fever is a general infection of the blood, Schotmüller's bacteriemia. Its localization in the lymphatic system of the alimentary tract is secondary and constant but not the only one possible. There are cases of typhoid starting with symptoms indicating the inflammation of the meninges, the kidneys or the lungs in which the presence of the Eberth bacillus in the blood is bacteriologically confirmed; the typical symptoms of typhus abdominalis, roseola,
LANDAU A, FEJGIN M. THE PECULIAR FORMS OF INFECTION CAUSED BY THE BACILLUS OF TYPHOID FEVER. Arch Intern Med (Chic). 1926;37(1):32-41. doi:10.1001/archinte.1926.00120190035003