It is a well known fact that small amounts of chlorides are found in the urine during the course of lobar pneumonia. It was shown in 1850 by Redtenbacher. It is a constant and as a rule so well pronounced a phenomenon that it can be used as a symptom of some diagnostic importance.
Of course a good deal of interest is attached to the pathologic basis of this phenomenon, and a good many investigators have been occupied with it, e. g., von Terray,1 Jochmann and Bittorf,2 von Hoesslin3, Scheel4 and others, but as far as I know no completely satisfactory explanation has been given.
The first question that arises is whether it is a genuine retention of chloride that exists during pneumonia. In such a highly febrile disease the patient of course eats little, and one might think that the slight excretion of chlorides was due to the slight
HOLTEN C. THE FORMATION OF ORGANIC ACIDS AND THE RETENTION OF CHLORIDES IN LOBAR PNEUMONIA. Arch Intern Med (Chic). 1926;38(4):489-501. doi:10.1001/archinte.1926.00120280081005