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Article
November 1926

A MODIFICATION OF THE UREA CONCENTRATION TEST

Author Affiliations

PHILADELPHIA

From the departments of medicine and physiologic chemistry, Jefferson Medical College Hospital.

Arch Intern Med (Chic). 1926;38(5):581-589. doi:10.1001/archinte.1926.00120290030004
Abstract

Many attempts have been made in recent years to develop a satisfactory test for the urea function of the kidney. Ambard presented his coefficient of urea excretion and F. C. McLean introduced the McLean index, which utilized the principles of Ambard's formula but simplified them. H. MacLean and de Wesselow1 brought out the urea concentration test. Addis2 studied the ratio between the one hour urine urea and the urea in 100 cc. of blood and Rabinowitz employed the urea concentration factorMany attempts have been made in recent years to develop a satisfactory test for the urea function of the kidney. Ambard presented his coefficient of urea excretion and F. C. McLean introduced the McLean index, which utilized the principles of Ambard's formula but simplified them. H. MacLean and de Wesselow1 brought out the urea concentration test. Addis2 studied the ratio between the one hour urine urea and the urea in 100 cc. of blood and Rabinowitz employed the urea concentration factorVarious investigators have shown that urea excretion in normal persons depends on the blood urea concentration as well as on the renal efficiency and also that the concentration of urea in the urine in normal persons can be increased indefinitely, under conditions compatible with life, by increasing the blood urea concentration. It has been further proved that the volume of water excreted has only a slight effect on urea excretionVarious investigators have shown that urea excretion in normal persons depends on the blood urea concentration as well as on the renal efficiency and also that the concentration of urea in the urine in normal persons can be increased indefinitely, under conditions compatible with life, by increasing the blood urea concentration. It has been further proved that the volume of water excreted has only a slight effect on urea excretion

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