In the recent advances made in the study of the capillaries, methods of visualization have played the larger rôle, with the result that most investigators have studied alterations in appearance rather than function, and if the latter, only indirectly. Much of the work has taken origin in the careful work of Otfried Müller1 and of Krogh.2 Stricker,3 Hooker4 and Ebbecke5 have devoted much time to a study of the functional alteration of the capillary and Ebbecke particularly to the bio-electrical changes that accompany or initiate changes in function. Ebbecke's work can be correlated with the clinicopathologic studies of the Kraus6 school on the ionic equilibrium of the body, particularly the calcium and potassium balance.
We have heretofore been accustomed to think of the capillary system and its functional control in terms of the vasomotor nervous mechanism and have come to confuse the reaction of the musculature of the arteriole with
PETERSEN WF, WILLIS DA. CAPILLARY PERMEABILITY AND THE INFLAMMATORY INDEX OF THE SKIN IN THE NORMAL PERSON AS DETERMINED BY THE BLISTER. Arch Intern Med (Chic). 1926;38(5):663-681. doi:10.1001/archinte.1926.00120290112012