Phenylhydrazine hydrochloride was used for the first time in the treatment of polycythemia vera in 1918 by Eppinger and Kloss.1 They used the drug in four cases in which the number of erythrocytes was satisfactorily reduced, and the symptoms were relieved without apparent injurious effects on the patient. Others2 on the continent have since reported their experiences. Owen3 was the first in this country to record experience with this method, and he has more recently4 amplified his previous report. Long,5 and Brown and Giffin6 have also attested its value.
So far as I know, quantitative metabolic studies have not been reported on patients with polycythemia vera during treatment with phenylhydrazine hydrochloride. Such studies not only should have academic interest, but should also furnish data by which the results of the treatment could be estimated.
The formula for phenylhydrazine is C6H5NH—NH2. The drug and its compounds have been used extensively in
HUFFMAN LD. METABOLIC STUDIES IN THE TREATMENT OF POLYCYTHEMIA VERA WITH PHENYLHYDRAZINE. Arch Intern Med (Chic). 1927;39(5):656-672. doi:10.1001/archinte.1927.00130050053006