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In this monograph Besredka presents a fascinating survey of the work of his school in its relation to local immunization. Incidentally, he has developed at some length his views on many phases of natural and acquired immunity. Starting from the observation that in staphylococcus, streptococcus and anthrax infections physicians deal primarily with a skin infection, and that with cholera, dysentery and typhoid they deal with a gastro-intestinal infection irrespective of the avenue of infection (intravenous, intraperitoneal, subcutaneous or by mouth), he develops the thesis that the protective immunization against these infections should be developed chiefly in the respective tissues. For immunization by mouth he has insisted repeatedly on the use of bile in preparing the way so that proper contact may be made with the bacteria ingested and the mucous membrane which is to be immunized. Interesting is his conclusion that the humoral antibodies play a relatively minor role in
Immunisation Locale.. Arch Intern Med (Chic). 1927;39(5):750. doi:10.1001/archinte.1927.00130050147018