It seems fair to say that the increasing difficulty in the diagnosis of cases with cerebral, or rather central nervous system, manifestations has not been lessened by the increased data concerning epidemic encephalitis and its bizarre symptomatology. One cannot help but feel that the recognition of this feature of encephalitis has led in great measure to a certain laxness in following puzzling cases to a definite conclusion.
Discussion as to the ultimate diagnosis in one fatal case gave rise to the question whether an apparently noninflammatory condition of the central nervous system could produce a spinal fluid like that in epidemic encephalitis or in other inflammatory conditions. Is increased protein (albumin and globulin) in the cerebrospinal fluid always a sign of inflammation? Could chronic nephritis with uremia, a supposedly noninflammatory condition in relation to the central nervous system, account for a similar picture?
Baar1 studied the diagnostic value of increased
LYTTLE JD, ROSENBERG L. CEREBROSPINAL FLUID IN NEPHRITIS. Arch Intern Med (Chic). 1927;39(6):808-816. doi:10.1001/archinte.1927.00130060060005