The anomaly of human bodily structure most often encountered is excessive storage of fat and, as a consequence, abnormal increase in weight. Only a few investigations have been made to ascertain the cause.
Obesity is generally divided into two groups: endogenous and exogenous; but a sharp distinction between the two has not been drawn. Some investigators consider as endogenous obesity only that type in which symptoms other than corpulence indicate an endocrine disease, while others are of the opinion that ultimately almost all cases of obesity are exogenous. However, there is much confusion on this point. It is certain that a regulation of the body weight takes place. When we consider what minimal amounts of fat must be stored per day in order to produce a considerable increase in weight and compare them with the daily intake of food, it is easily seen that this regulation must be delicate, so
HAGEDORN HC, HOLTEN C, JOHANSEN AH. THE PATHOLOGY OF METABOLISM IN OBESITY. Arch Intern Med (Chic). 1927;40(1):30-37. doi:10.1001/archinte.1927.00130070033002