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April 1928


Author Affiliations


From the Otho S. A. Sprague Memorial Institute and the Pathological Laboratory of the Cook County Hospital.

Arch Intern Med (Chic). 1928;41(4):549-557. doi:10.1001/archinte.1928.00130160099006

In a recent publication, Feldman and Reifsneider1 briefly reviewed previous work with the intradermal salt solution test2 and reported results of its use in a series of cases of nephritis. McClure and Aldrich,3 who introduced the test in 1923, found that the elevation produced by the injection of salt solution disappeared more quickly than normally in the presence of edema or pre-edema. They 3 suggested the possibility that the rapid disappearance of the type studied in cases of edema with associated albuminuria might be due to a toxic condition of the tissues which increases their affinity for water. Results from the use of the test by Baker4 in scarlet fever, by Lash5 in toxemia of pregnancy, by Olmstead6 in a certain group of cardiac cases and by Harrison7 in pneumonia in children, tend to show a relationship between the toxicity or severity of illness of the patient and the disappearance

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