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May 1928

IODINE COMPOUNDSTHEIR SELECTIVE ABSORPTION BY THE HYPERPLASTIC THYROID GLAND OF THE DOG

Author Affiliations

CHICAGO

From the Department of Physiological Chemistry and Pharmacology, The University of Chicago.

Arch Intern Med (Chic). 1928;41(5):615-621. doi:10.1001/archinte.1928.00130170002001
Abstract

Marine and Feiss1 and Marine and Rogoff2 have demonstrated both by perfusion of the surviving isolated organ and by injections in vivo that the thyroid gland is able to remove iodide iodine from circulating fluids with extreme rapidity. Apparently no one, however, has studied iodine in other forms which are sometimes believed to behave characteristically when administered to persons suffering from disorders of the thyroid gland. The experiments reported in this paper have therefore been undertaken to learn, if possible, to what extent compounds containing iodine other than iodide iodine are selectively absorbed by the thyroid gland.

TECHNIC  In all of the experiments, the selective absorption of the various iodine compounds by the dog's hyperplastic thyroid gland was determined in vivo. When the preliminary experiments were performed about three years ago,3 a large proportion of the animals had suitable goiters. In attempting to complete the work recently, I had great

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