As reported elsewhere,1 chronic interstitial nephritis is readily produced in dogs by direct roentgen-ray irradiation of the kidneys. The functional aspect of this experimental disease, as far as the usual tests are concerned, has also been recorded,2 and reference has been made to a combined renal function test consisting of the injection of sodium thiosulphate, sodium iodide and phenolsulphonphthalein. The present investigation deals with the excretion of these three substances throughout a course of experimental disease of the kidneys. Subsequently, this combined test was also applied to a large group of normal animals. Observations on normal animals led to an investigation concerning the behavior of normal pregnant animals toward the combined test. The latter are also reported in this paper.
Nyiri3 called attention to the usefulness of sodium thiosulphate as an agent for tests of renal function. He also proposed a combination of the sodium thiosulphate tests with the two
BOLLIGER A. RENAL FUNCTION TESTS WITH SODIUM THIOSULPHATE AND SODIUM IODIDEAN EXPERIMENTAL COMPARISON WITH THE PHENOLSULPHONPHTHALEIN TEST. Arch Intern Med (Chic). 1928;41(5):642–654. doi:10.1001/archinte.1928.00130170029004