It is assumed in this paper that acromegaly is a constitutional disease of adult life due to overactivity of the anterior lobe of the pituitary gland, manifest pathologically by a hyperplastic or adenomatous process composed of acidophilic cells1. Since the first comment on the frequent occurrence of mellituria in persons with tumor of the hypophysis, made by Loeb2 in 1884, there has been much experimentation and much discussion concerning the relationship of the pituitary gland to the diabetes. The hypotheses thus far advanced are:
In the hypothalamus in the neighborhood of the hypophysis, there is a center which regulates carbohydrate metabolism. In acromegaly, the pressure of a large tumor of the pituitary gland on this center causes the diabetes.
The glycosuria is due to secondary changes in the pancreas.
There is a disturbance of the internal secretion of the thyroid gland, which impairs the functional ability of the islands
YATER WM. ACROMEGALY AND DIABETESREPORT OF SIX CASES. Arch Intern Med (Chic). 1928;41(6):883–912. doi:10.1001/archinte.1928.00130180116008