About a decade ago, I began making observations on patients with exophthalmic goiter to determine their degree of tolerance to the ingestion of quinine. Part of the deductions derived were published in the nature of a description of the quinine test1 for patients with exophthalmic goiter. Up to December, 1927, tolerance for quinine was studied in 500 patients. Following my preliminary reports, others made similar observations. Among those, Sainton and Schulman2 arrived at negative conclusions, but their data were based on only ten cases. Pfahler,3 on the other hand, found the quinine test extremely useful.
THE QUININE TEST AND RESULTS OF USE OF THIS DRUG
The technic of the test consists in giving the patient a dozen capsules each containing 10 grains (0.65 Gm.) of quinine hydrobromide or quinine sulphate, with instructions to take a capsule four times a day. When 20 or 30 grains (1.3 or 1.9 Gm.) have
BRAM I. TOLERANCE FOR QUININE IN EXOPHTHALMIC GOITER. Arch Intern Med (Chic). 1928;42(1):53-55. doi:10.1001/archinte.1928.00130190056005