During the course of investigations dealing with a correlation of skin reactions with the blood chemistry and certain cardiovascular renal reactions, we have had occasion to study the effect of subcutaneous injections of epinephrine on the blood pressure of one hundred so-called "normal" men, as well as on about fifty patients who were ill from various diseases (glaucoma, exophthalmic goiter and other conditions). It is our purpose to enter into an analysis of these correlations in this paper.
It is agreed, we believe, that the original efforts of Eppinger and Hess1 to classify all persons into groups that were vagotonic or sympathicotonic proved unsatisfactory, indeed confusing. There is no doubt that the emphasis placed on the study of the autonomic reactions of the patient has contributed immensely to the concept of the underlying factors of a number of disease conditions, but this study has added, for the time being at
PETERSEN WF, LEVINSON SA, ARQUIN S. THE RELATION OF THE REACTION TO EPINEPHRINE TO THE POTASSIUM-CALCIUM RATIO AND OTHER RATIONS. Arch Intern Med (Chic). 1928;42(2):256-269. doi:10.1001/archinte.1928.00130200108007