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While ephedrine has been employed in Chinese medicine for over five thousand years, it has been only in the past five years, since its reisolation and careful study by Chen and Schmidt, that modern medicine has added it to the list of drugs in daily use. In 1923, Chen called attention to ephedrine and conducted a careful study of its physiologic effect, so that in a short time the drug became popularized and freely used by practitioners of medicine and even by laymen.
At the present time, the drug is widely used for a variety of conditions, and the literature contains many interesting and instructive articles regarding its pharmacology, mode of action and therapeutic uses.
From time to time attention has been called to certain untoward effects from the use of this drug, and it is not considered amiss at this time to emphasize the point that this drug is
BLOEDORN WA, DICKENS PF. DANGER OF THE ADMINISTRATION OF EPHEDRINE IN HEART FAILURE. Arch Intern Med (Chic). 1928;42(3):322-330. doi:10.1001/archinte.1928.00020020010002