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Article
April 1929

OPIUM ADDICTIONIII. THE CIRCULATION AND RESPIRATION OF HUMAN ADDICTS DURING THE ADMINISTRATION OF MORPHINE

Author Affiliations

PHILADELPHIA

From the Narcotic Wards of the Philadelphia General Hospital.

Arch Intern Med (Chic). 1929;43(4):556-567. doi:10.1001/archinte.1929.00130270130010
Abstract

The data presented in this paper have been accumulated from the study of a number of opium addicts for the purpose of determining whether prolonged addiction to the drug or its derivatives has brought about any detectable changes in the behavior of the circulatory system. We have studied the heart and circulation not only while the addict was at rest in bed but when he was subjected to a standardized physical task. As a basis for comparison, similar tests were conducted on trained and untrained persons not addicted to opium. This paper also includes an electrocardiographic study as well as orthodiagrammatic measurements of addicts while morphine was being administered. It also contains the effects of the injection of atropine sulphate on the heart rate and P-R interval in a series of addicts while they were receiving morphine.

EXPERIMENTAL PROCEDURE  All the experiments and measurements were performed during the morning, usually

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