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Article
November 1929

EOSINOPHILIC HYPERLEUKOCYTOSIS IN HODGKIN'S DISEASE WITH FAMILIAL EOSINOPHILIC DIATHESISREPORT OF A CASE AND REVIEW OF THE LITERATURE

Author Affiliations

PHILADELPHIA

From the Medical Division, Hospital of the University of Pennsylvania.

Arch Intern Med (Chic). 1929;44(5):772-783. doi:10.1001/archinte.1929.00140050149012
Abstract

Moderate leukocytosis and slight eosinophilia have long been regarded as common components of the clinical picture of Hodgkin's disease. In few cases of authentic Hodgkin's disease, however, has there been recorded an excessive increase in eosinophilic cells of such magnitude as to warrant the designation "eosinophilic hyperleukocytosis." Such hyperleukocytosis, with absolute eosinophilia, has also been mentioned in association with various other unrelated diseases and has been described independently as an unclassified clinical syndrome. The following case is reported because, as a case of Hodgkin's disease, it is unique, both in the height of the leukocyte count and in the percentage and absolute number of mature eosinophils; and also, because it offers a possible explanation for this most unusual response of the bone-marrow.

REPORT OF CASE 

History.  —E. H., a woman, aged 35, was admitted on Sept. 14, 1928, to the University Hospital, service of Dr. Alfred Stengel, with enlarged nodes

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