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Article
December 1929

THE RATE OF GLYCOLYSIS IN ERYTHREMIA (POLYCYTHEMIA VERA)

Author Affiliations

ST. LOUIS

From the Medical Service of the Jewish Hospital.

Arch Intern Med (Chic). 1929;44(6):813-817. doi:10.1001/archinte.1929.00140060028003
Abstract

In a recent article by Falcon-Lesses,1 the author applied the observations of Warburg and Murphy and Hawkins on glycolysis in malignant disease to the apparently similar problem of glycolysis in leukemic blood. He found that, whereas in normal persons glycolysis in blood containing not more than 100 mg. of dextrose per hundred cubic centimeters is completed in about six hours, in the blood of patients with myelogenous leukemia the process was from two to three times as rapid, being complete in from one to four hours.

In seeking some explanation of the mechanism of this process, Falcon-Lesses made observations in two other cases showing abnormal conditions of the blood, one of polycythemia with a red cell count of 9,505,000 and a white cell count of 25,775 and the other a case of pernicious anemia with a red cell count of 2,800,000 and a white cell count of 4,000. The rate

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