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Article
December 1929

OPIUM ADDICTIONX. THE EXCRETION OF MORPHINE BY HUMAN ADDICTS

Author Affiliations

PHILADELPHIA

From the Narcotic Wards of the Philadelphia General Hospital and the Laboratory of Pharmacology, University of Pennsylvania.

Arch Intern Med (Chic). 1929;44(6):862-869. doi:10.1001/archinte.1929.00140060077008
Abstract

The relation between the capacity of the animal body to destroy morphine and its power of developing tolerance to the drug following repeated dosage has been of interest to pharmacologists for many years. Recent study with the aid of improved chemical methods indicates that Faust's1 conclusion, that a direct, casual relationship between the two phenomena exists, is incorrect. It seemed important to collect from human material such data as might bear on this subject. The study here reported concerns the excretion of morphine by human addicts; the difference between the amounts of morphine administered and those excreted is to be regarded as a measure of morphine destroyed.

While it is well known from the early observations of Kauzmann,2 Vogt,3 and Jacques4 that morphine is eliminated in the urine and feces of human addicts, its quantitative excretion in these channels has, to our knowledge, not been studied. In the subjects whom

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