June 1930


Arch Intern Med (Chic). 1930;45(6):827-867. doi:10.1001/archinte.1930.00140120002001

EXPERIMENTAL PRODUCTION OF PAIN ON EXCITATION OF THE HEART AND GREAT VESSELS  In work previously reported,1 a method has been described for temporary occlusion of the coronary vessels in the unanesthetized dog, and also methods for the study of the production of pain and its transmission. This work was originally begun with the idea of studying the effects of temporary occlusion of the coronary vessels on the supposition that in this way we might simulate angina pectoris, if the theory that angina is produced by a temporary spasm of the coronary vessels is accepted.As the work progressed, itbecame necessary to eliminate extraneous causes for pain,2 which resulted in the study of pain sensation in the visceral and parietal pericardium, the myocardium and the great vessels, especially the first portion of the aorta. As a result, this investigation developed into three phases: (1) the physiologic effects of temporary occlusion of

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