Investigations into the state of the blood calcium in diseases accompanied by jaundice have been carried out mainly in three directions: the direct examination of the total calcium content of the whole blood, serum or plasma of jaundiced patients and experimental animals; the determination of the toxicity of bile and bile salts as modified by the action of calcium salts, and the injection of these into the blood stream of experimental animals; and by therapy with calcium salts, cod liver oil and ultraviolet radiation, and by the action of extract of parathyroid hormone in experimental animals and in man.
The most consistently and most widely quoted works are those of King and Stewart,1 Lee and Vincent,2 Vines,3 Groves and Vines,4 Kirk and King5 and Walters and Bowler.6 It is largely on the basis of these investigations, in which the three methods of approach mentioned were employed, that the current opinion
GUNTHER L, GREENBERG DM. I. THE DIFFUSIBLE CALCIUM AND THE PROTEINS OF THE BLOOD SERUM IN JAUNDICE. Arch Intern Med (Chic). 1930;45(6):983-1003. doi:10.1001/archinte.1930.00140120158009